iReceptor congratulates Prof. George P. Smith, who will receive a 2018 Nobel Prize in Chemistry this December for his invention of phage display, and pioneering work on phage-library technology.
As a postdoc with Prof. Smith, iReceptor Co-PI Dr. Jamie K. Scott helped produce the proof of concept for phage-displayed peptide libraries. This technique has been used by 100s of researchers and biopharma companies to develop monoclonal antibodies against autoimmune diseases and discover targets for vaccine research. Dr. Scott has continued to lead in this field, including her work with the iReceptor team in the development of a platform for the storage and analysis of AIRR-seq data generated by labs using phage display.
Read the 3 papers that started the field:
-Invention of phage display (Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 1985)
– Improving phage display and affinity selection (Parmley SF, Smith GP. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 1988)
– Proof of concept for phage-displayed peptide libraries (Scott JK, Smith GP. Searching for peptide ligands with an epitope library. Science 1990)