What is iReceptor?

iReceptor facilitates the curation, analysis and sharing of antibody/B-cell and T-cell receptor repertoires (Adaptive Immune Receptor Repertoire or AIRR-seq data) from multiple labs and institutions. We are committed to providing a platform for researchers to increase the value of their data through sharing with the community. This will greatly increase the amount of data available to answer complex questions about the adaptive immune response, accelerating the development of vaccines, therapeutic antibodies against autoimmune diseases, and cancer immunotherapies. Visit the COVID-19 page for a list of curated COVID-19 AIRR-seq studies.

Our Approach

The iReceptor Gateway integrates large, distributed, AIRR-seq data repositories, following standards for sharing and interoperability developed by the Adaptive Immune Receptor Repertoire (AIRR) Community. The main goal of iReceptor is to connect this distributed network of AIRR-seq repositories into an AIRR Data Commons, allowing queries across multiple projects, labs, and institutions.

Present functionalities include:

  • Search for repertoires satisfying certain metadata (e.g. find all AIRR-seq repertoires from ovarian cancer studies)
  • Search for all repertoires that contain specific CDR3 sequences
  • Search identified repertoires for sequences derived from particular V, D, and J genes and alleles
  • Download sequences from these repertoires in AIRR.tsv format, easily importable to other AIRR-seq analysis tools

iReceptor is a member of the iReceptor Plus Consortium. This project will expand the analysis tools available on the Gateway, including for single cell or systems immunology approaches, and add security for iReceptor Plus repositories.

Users of the iReceptor Gateway can search AIRR-seq data from studies on ovarian cancer, autoimmune diseases such as MS and SLE, and infectious diseases such as COVID-19 and HIV.  Visit the iReceptor Studies page for a list of curated studies.

2.7 billion sequences and 2733 repertoires are currently available, from 3 remote repositories, 40 research labs and 44 studies with:

Researchers interested in sharing data or exploring the AIRR Data Commons through the open iReceptor Gateway should visit www.ireceptor.org and for an account contact support@ireceptor.org. For more information about the iReceptor approach and architecture, please see the paper iReceptor: a platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories.

Funding

iReceptor is a project located at the IRMACS Centre at Simon Fraser University. It is funded by the CANARIE Network Enabled Platforms Program, the Canada Foundation for Innovation (CFI), the British Columbia Knowledge Development Fund (BCKDF), the Canadian Institute for Health Research, the European Union’s Horizon 2020 research and innovation programme (grant agreement No 825821), and Simon Fraser University. The iReceptor project is part of the EU/CIHR funded iReceptor Plus Consortium.

How to Acknowledge iReceptor

If you find iReceptor useful in your research, please acknowledge the iReceptor Platform's contribution by citing the iReceptor paper by Corrie et al. iReceptor: a platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories, Immunological Reviews, Volume 284:24-41 (2018).