What is iReceptor?

iReceptor is a distributed data management system and scientific gateway for mining “Next Generation” sequence data from immune responses. The main goal of iReceptor is to connect a distributed network of NGS (next-generation sequencing) databases for antibody/B-cell or T-cell receptor repertoires, allowing queries among data sets from multiple projects and institutions/labs. Integrating these important databases will result in the improvement of the design of vaccines, therapeutic antibodies and cancer immunotherapies. 

iReceptor will provide a technology platform that will lower the barrier to immune genetics researchers who need to federate large, distributed, immune genetics data repositories in order to answer complex questions about the immune response. The focus of the iReceptor project is to leverage existing capabilities and technologies to build a new scientific platform for the immune genetics research community. In order to provide such a system, the iReceptor project will develop the following components:

  • An iReceptor immune genetics data model and data repository design that enhances existing genomics data models,
  • A set of data adaptor/import/conversion services for transforming immune genetics data sets into the iReceptor data model,
  • An iReceptor data service that will expose access to a set of distributed immune genetics data repositories,
  • A set of iReceptor computational services that provide researchers access to advanced computational resources for the analysis of immune genetics data,
  • A scientific gateway web platform (based on the Agave software stack) that ties these components together to enable a new type of immune genetics research.

A summary of the data accessible through the iReceptor Gateway, as of October 2017. Data is added continually as more research data is curated. Please go to the iReceptor Gateway and sign up for an account if you would like to explore this data.

The iReceptor project is working closely with international partners to develop both the foundational biological and immune genetics requirements for reporting these data, as well as to develop the technological components of the iReceptor Scientific Gateway. The AIRR Community Initiative was formed to develop  protocols and best practices to facilitate comparing and sharing Adaptive Immune Receptor Repertoire (AIRR data airr-community.org). The iReceptor project team is working with the Agave Scientific Gateway team from the Texas Advanced Computing Centre to design and develop the technological platform on which iReceptor will be based.

iReceptor is a project located at the IRMACS Centre at Simon Fraser University. It is funded by the CANARIE Network Enabled Platforms Program, the Canada Foundation for Innovation (CFI), the British Columbia Knowledge Development Fund (BCKDF), and Simon Fraser University.

Researchers can use the iReceptor Scientific Gateway by applying for an account and logging in to the web interface here. To apply for an account, please send an email to ireceptor-help@sfu.ca.