What is iReceptor?

iReceptor is a distributed data management system and scientific gateway for mining “Next Generation” sequence data from immune responses. The goal of the project is to: improve the design of vaccines, therapeutic antibodies and cancer immunotherapies by integrating Canadian and international data repositories of antibody and T-cell receptor gene sequences.

iReceptor will provide a technology platform that will lower the barrier to immune genetics researchers who need to federate large, distributed, immune genetics databases in order to answer complex questions about the immune response. The focus of the iReceptor project is to leverage existing capabilities and technologies to build a new scientific platform for the immune genetics research community. In order to provide such a system, the iReceptor project will develop the following components:

  • An iReceptor immune genetics data model and database design that enhances existing genomics data models,
  • A set of data adaptor/import/conversion services for transforming immune genetics data sets into the iReceptor data model,
  • An iReceptor data service that will expose access to a set of distributed immune genetics databases,
  • A set of iReceptor computational services that provide researchers access to advanced computational resources for the analysis of immune genetics data,
  • A scientific gateway web platform (based on the Agave software stack) that ties these components together to enable a new type of immune genetics research.

The iReceptor project is working closely with international partners to develop both the foundational biological and immune genetics requirements as well as to develop the technological components of the iReceptor Scientific Gateway. iReceptor is working with the Agave scientific gateway team from the Texas Advanced Computing Centre to design and develop the technological platform on which iReceptor will be based. The iReceptor team works closely with the AIRR Community to develop protocols and best practices to facilitate comparing and sharing Adaptive Immune Receptor Repetoire (AIRR) data.

iReceptor is a project located at the IRMACS Centre at Simon Fraser University. It is funded by the CANARIE Network Enabled Platforms Program, the Canada Foundation for Innovation (CFI), the British Columbia Knowledge Development Fund (BCKDF), and Simon Fraser University.