Provenance: t1d-1.ireceptor.org

  • 2024-03-12: Updated gene calls for Adaptive's incorrectly named genes (according to AIRR suggested nomenclature)
    • Updated Mitchell et al. and Seay et al. with corrected VDJ gene nomenclature calls
    • Genes that were changed can be found in the Adaptive-Fix github directory on the iReceptor github - https://github.com/sfu-ireceptor/sandbox/tree/0aaa7828f60e53e6006abfdb0c...
    • Summary of changes at the gene level (appropriate allele changes also made - e.g. TRBV1-1*01 to TRBV1*01):
      • TRBV1-1 to TRBV1 - 124871 sequences
      • TRBV2-1 to TRBV2 - 2309941 sequences
      • TRBV9-1 to TRBV9 - 2577037 sequences
      • TRBV13-1 to TRBV13 - 550833 sequences
      • TRBV14-1 to TRBV14 - 829030 sequences
      • TRBV15-1 to TRBV15 - 901472 sequences
      • TRBV16-1 to TRBV16 - 60085 sequences
      • TRBV17-1 to TRBV17 - 1965 sequences
      • TRBV18-1 to TRBV18 - 1712890 sequences
      • TRBV19-1 to TRBV19 - 3569313 sequences
      • TRBV26-1 to TRBV26 - 436 sequences
      • TRBV27-1 to TRBV27 - 3042168 sequences
      • TRBV28-1 to TRBV28 - 3132593 sequences
      • TRBV30-1 to TRBV30 - 1635960 sequences
      • TRBD1-1 to TRBD1 - 42629748 sequences
      • TRBD2-1 to TRBD2 - 42797994 sequences
  • 2024-02-07: Study added
    • 32 Million annotated sequences from Gomez-Tourino et al., "T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes"
  • 2023-12-07: Study added
    • 6 Thousand annotated sequences from Anderson et al., "Human islet T cells are highly reactive to preproinsulin in type 1 diabetes"
  • 2023-04-04: Study added
    • 6.9 Million annotated sequences from Seay et al., "Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes"
  • 2023-01-19: Study added
    • 62 Million annotated sequences from Mitchell et al., "Temporal development of T cell receptor repertoires during childhood in health and disease", including subject MHC/HLA typing.
  • 2023-01-19: Repository on line.