In collaboration with the AIRR Community, we are pleased to announce the second COVID-19 AIRR-seq study available for searching and download through the iReceptor Gateway. 87 Million annotated sequences from the pre-press paper Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection from Minervina, et al. have been loaded into the AIRR COVID-19 repository.
The Research Data Alliance (RDA) is a community-driven initiative that provides a neutral space for more than 10k members from 145 countries to come together through focused global Working and Interest Groups to develop and adopt infrastructure that promotes data-sahring and data-driven research. The RDA's mission is to build the social and technical bridges to enable the open sharing and re-use of data.
In collaboration with the AIRR Community, we are pleased to announce the first COVID-19 AIRR-seq study available for searching and download through the iReceptor Gateway. 8.9 Million annotated sequences from the paper B cell clonal expansion and convergent antibody responses to SARS-CoV-2 from Nielsen, et al. has been loaded into the AIRR COVID-19 repository. We expect a number of other papers to be added to this repository in the near future.
The iReceptor v3.0 upgrade implements the recently released AIRR v1.3 standard. All repositories in the iReceptor Public Archive have been upgraded.
The iReceptor Gateway and the iReceptor Public Archive (IPA1 through IPA5) will be down for maintenance and a software upgrade from 11:00 - 15:00 Pacific time, June 4th.
Sorry for the inconvenience...
Members of the iReceptor team are hacking throughout the weekend on a project called “Adaptive ImmunoSeq Repository as part of the ./hackseq-rna virtual COVID-19 Ultra Hackathon. Microsoft and Adaptive Biotechnologies are exploring how the immune system responds to COVID-19 and the 3 day goal is to develop a tool to query the Adaptive ImmunoSeq repository (using their WebAPIs), download data, and convert it to the standard AIRR-seq data formats for Repertoires and Rearrangements.
The iReceptor Gateway and repositories experienced a short outage due to networking problems on our service provider Compute Canada. All services were down from 12:16 - 14:57 Pacific time on 2020/05/07. All systems and services are back on line.
In collaboration with the AIRR Community and in response to the AIRR Community's call for sharing COVID-19 related AIRR-seq data the iReceptor Project has prepared an iReceptor Turnkey Repository and the project team is prepared to curate public COVID-19 data on behalf of the community.
Two studies out of China have used immune profiling platform developed by 10X Genomics, one of the partners in the iReceptor Plus Consortium, to examine the immune systems of COVID-19 patients at the level of single cells. Liao et al.
The AIRR Community recently made a public call for the sharing of AIRR-seq data. In their call they state "...
