iReceptor founders Felix Breden and Jamie Scott recently published an overview of the AIRR Community as part of a volume edited by Professor Ramit Mehr in Current Opinion in Systems Biology.
In collaboration with the AIRR Community, we are pleased to announce the eleventh COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 18.9M annotated sequences from Montague et. al. Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity have been loaded into the VDJServer repository and are now available through the iReceptor Gateway.
A recent preprint uploaded to bioRxiv shows the power of the iReceptor Gateway to integrate data from multiple labs and institutions, in this case to help study the adaptive immune response to COVID-19. Meysman and colleagues (Tracking SARS-CoV-2 T cells with epitope-T-cell receptor recognition models, published Sep 9) compared longitudinal data from Minervina et al. and Schultheiß et al. to examine how T-cells that react to SARS-CoV-2 behave during disease progression.
The iReceptor team was recently awarded CANARIE Research Data Management funding to extend the iReceptor Gateway. The project, "Towards Systems Immunology: Integrating FAIR data into the iReceptor Platform" will help the iReceptor platform integrate a number of important immunology related data beyond the standard AIRR-seq data, such as single cell sequencing and germline integration. Thank you to CANARIE for their continued support!
In collaboration with the AIRR Community, we are pleased to announce the tenth COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 542 M annotated sequences from Nolan et.
Felix Breden, Scientific Director of iReceptor, was interviewed by the Financial Times on the efforts of the iReceptor team to curate multiple studies of COVID-19 patients. In a broad-ranging article on immunogenetics approaches to COVID-19 research, Dr.
In collaboration with the AIRR Community, we are pleased to announce the ninth COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 12 M annotated sequences from Kuri-Cervantes et. al Comprehensive mapping of immune perturbations associated with severe COVID-19 have been loaded into the AIRR COVID-19 repository and are now available through the iReceptor Gateway.
From 18:00 August 24 to 08:00 August 25 one of the IPA servers was down. During this time 452 Million sequence annotations from Zvyagin et al "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" were unavailable. All services are now back on line.
Network outage Aug 25 07:00 - 07:30 PST
iReceptor's infrastructure provider, Compute Canada, has a scheduled network outage on Tuesday August 25 between 7:00-7:30 PDT/10:00-10:30 EDT. The outage is expected to be less than 2 minutes, but could be up to 20 minutes. All iReceptor services may be impacted by this outage.
Research Data Canada recently created a comprehensive blog post highlighting the iReceptor Gateway's rapid response to the COVID-19 pandemic. The Gateway facilitaties interoperable data sharing accelerates diagnostics and vaccine development.