The iReceptor team is happy to announce a powerful new Repertoire Statistics capability on the iReceptor Gateway, enabling users to interactively explore VDJ gene usage statistics as well Junction/CDR3 length frequencies.
In collaboration with the Yaari Lab at Bar Ilan University in Israel and the iReceptor Plus project we are pleased to announce the Fourth repository in the AIRR Data Commons. The VDJBase AIRR-seq repository is a community resource hosted and supported by the Yaari Lab group and the iReceptor team. We look forward to having data added to this repository as well as the addition of new repositories in the AIRR Data Commons in the near future.
In collaboration with the AIRR Community, we are pleased to announce the thirteenth COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 212K annotated sequences from Mor et al. Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors have been loaded into the AIRR COVID-19 repository and are now available through the iReceptor Gateway.
The iReceptor Gateway is back - services are restored!
Outage notification: There is an outage on our service provider for authentication at the Texas Advanced Computing Centre (TACC). They are working on the problem and we expect the service to be back soon. Apologies for any inconveniences, we will report when services are back on line.
In collaboration with the AIRR Community, we are pleased to announce the twelfth COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 125K annotated sequences from Wen et. al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing have been loaded into the AIRR COVID-19 repository and are now available through the iReceptor Gateway.
iReceptor founders Felix Breden and Jamie Scott recently published an overview of the AIRR Community as part of a volume edited by Professor Ramit Mehr in Current Opinion in Systems Biology.
In collaboration with the AIRR Community, we are pleased to announce the eleventh COVID-19 AIRR-seq study available for searching and download in the AIRR Data Commons and through the iReceptor Gateway. 18.9M annotated sequences from Montague et. al. Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity have been loaded into the VDJServer repository and are now available through the iReceptor Gateway.
A recent preprint uploaded to bioRxiv shows the power of the iReceptor Gateway to integrate data from multiple labs and institutions, in this case to help study the adaptive immune response to COVID-19. Meysman and colleagues (Tracking SARS-CoV-2 T cells with epitope-T-cell receptor recognition models, published Sep 9) compared longitudinal data from Minervina et al. and Schultheiß et al. to examine how T-cells that react to SARS-CoV-2 behave during disease progression.
The iReceptor team was recently awarded CANARIE Research Data Management funding to extend the iReceptor Gateway. The project, "Towards Systems Immunology: Integrating FAIR data into the iReceptor Platform" will help the iReceptor platform integrate a number of important immunology related data beyond the standard AIRR-seq data, such as single cell sequencing and germline integration. Thank you to CANARIE for their continued support!